DAB2IP Regulates Autophagy in Prostate Cancer in Response to Combined Treatment of Radiation and a DNA-PKcs Inhibitor

Radiation therapy (RT) is an effective strategy for the treatment of localized prostate cancer (PCa) as well as local invasion.However, some locally advanced cancers develop radiation resistance and recur after therapy; therefore, the development of radiation-sensitizing compounds is essential for treatment of these tumors.DOC-2/DAB2 interactive pr

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Nanomaterials and Nanotechnology-Associated Innovations against Viral Infections with a Focus on Coronaviruses

Viral infections have recently emerged not only as a health threat to people but rapidly became the cause of universal fatality on a large scale.Nanomaterials comprising functionalized nanoparticles (NPs) and quantum dots and nanotechnology-associated innovative detection methods, vaccine design, and nanodrug production have shown immense promise f

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A Robust Adaptive Chattering-Free Sliding Mode Control Strategy for Automotive Electronic Throttle System via Genetic Algorithm

A robust adaptive chattering-free sliding mode (ACFSM) control method for electronic throttle (ET) system is proposed in this paper.It is well known that nonlinearities in the throttle system including friction, return-spring, limp-home (LH) and gear backlash affect the control accuracy of the throttle valve.Compared with the traditional sliding mo

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Single Depot Multiple Travelling Salesman Problem Solved With Preference-Based Stepping Ahead Firefly Algorithm

Firefly Algorithm (FA) mimics the flashing light characteristic of fireflies to solve optimization problems.An area where its utilization is limited is Travelling Salesman Problem (TSP).There are a number of algorithms utilized to solve the problem; however, there is still scope to do better in terms of solution quality.In this study, stepping ahea

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